It has long been understood that the pathogenesis of complex diseases such as diabetes includes both genetic and environmental components. Furthermore, recent evidence suggests that diet-induced metabolic changes in mammals are transmitted from father to the offspring, suggesting sperm mediated epigenetic inheritance. Our laboratory is interested in understanding how nutrition during early mammalian development increases diabetes risk on exposed individuals and their progeny. Epigenetic mechanisms may link early nutritional imbalances with permanent changes in gene expression that lead to adult disease risk. Likewise, epigenetic mechanisms may also mediate nutritionally-induced inheritance of such phenotypes if the epigenetic alterations occur in cells from the germ line. We have previously developed a mouse model of transgenerational non-genomic inheritance of diabetes risk by neonatal malnutrition. We are currently investigating the potential role of DNA methylation and small non-coding RNAs in mediating disease risk and transgenerational effects.
We are seeking a candidate eligible to apply for “BECAS DE POSTDOCTORADO EN EL EXTRANJERO BECAS CHILE – CONVOCATORIA 2016”, CONICYT, Chile.
List of recent related publications
– Jimenez-Chillaron et al., Epigenetics, 2015
– Martinez et al., Cell Metabolism, 2014 – Radford et al., PLoS Genetics, 2012
– Pentintat et al., Endocrinology, 2010
– Jimenez-Chillaron et al., Diabetes, 2009
Interested candidates, fulfilling the eligible criteria for “BECAS DE POSTDOCTORADO EN EL EXTRANJERO BECAS CHILE – CONVOCATORIA 2016” are strongly advised to submit a covering letter and CV to Dr. Jimenez-Chillaron, no later than 1st July 2016